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Thursday Night Football Preview: Seahawks vs Cardinals – Week 4 Picks

It’s Thursday Night Football, and the spotlight is on a classic NFC West showdown as the Seattle Seahawks travel to face the Arizona Cardinals. Division games under the lights always bring extra juice, and tonight we’ve got two teams battling to set the tone early in the season.

Let’s start with the total. The number sits at 43.5, and both squads have strong Over trends in September.

  • Seattle has gone Over in 7 of its last 9 September games.

  • Arizona has gone Over in 6 of its last 9 September games.

Seattle’s offense has been producing explosive plays, while Arizona tends to push tempo at home. With both defenses showing cracks against big plays, the path is clear for points on the board. A 24–21 or 27–23 type of game gets us Over the number. The play here is the Over 43.5, Medium confidence.

Now for the side, which I consider the Top Play of the Night. The spread is essentially a pick’em with Seattle catching +1. While Arizona has won 6 of its last 7 games at home overall, the head-to-head history against Seattle is completely lopsided.

  • Seattle is 7–0 straight up in its last 7 games vs Arizona.

  • Seattle is 6–1 against the spread in the last 7 matchups.

  • Seattle is 7–1 straight up in its last 8 trips to Arizona.

That’s not just a trend—that’s dominance. Seattle has also won seven straight road games overall, proving they travel well. While Arizona brings a competitive home edge, history and current form both tilt toward the Seahawks.

Recap:

  • Total: Over 43.5 (Medium Confidence)

  • Side: Seattle -1 (Medium-High Confidence, Top Play of the Night)

The Seahawks have owned this matchup, and I expect them to keep that streak alive under the Thursday night lights. Good luck, and let’s cash these tickets.